Apigenin

  • GreenMolBD CID : 875
  • Molecular Formula : C15H10O5
  • Molecular Weight : 270.24
  • Exact Molecular Mass : 270.053
  • IUPAC Name : 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
  • InChI : InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
  • InChI Key : KZNIFHPLKGYRTM-UHFFFAOYSA-N
  • Canonical SMILES : C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
  • Isomeric SMILES : c1cc(ccc1c2cc(=O)c3c(cc(cc3o2)O)O)O
  • Cross Reference  Pubchem

1. Classification

1.1. Description

This compound belongs to the class of organic compounds known as flavones. These are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one).

1.2. Taxonomy Tree

1.3. Alternative Parent

7-hydroxyflavonoids; 5-hydroxyflavonoids; 4'-hydroxyflavonoids; Chromones; Pyranones and derivatives; 1-hydroxy-4-unsubstituted benzenoids; 1-hydroxy-2-unsubstituted benzenoids; Benzene and substituted derivatives; Vinylogous acids; Heteroaromatic compounds; Oxacyclic compounds; Organooxygen compounds; Organic oxides; Hydrocarbon derivatives;

1.4. Molecular Framework

Aromatic heteropolycyclic compounds

1.5. Substituents

4'-hydroxyflavonoid; 5-hydroxyflavonoid; 7-hydroxyflavonoid; Flavone; Hydroxyflavonoid; Chromone; Benzopyran; 1-benzopyran; 1-hydroxy-4-unsubstituted benzenoid; 1-hydroxy-2-unsubstituted benzenoid; Phenol; Pyranone; Monocyclic benzene moiety; Benzenoid; Pyran; Vinylogous acid; Heteroaromatic compound; Organoheterocyclic compound; Oxacycle; Organic oxygen compound; Organooxygen compound; Organic oxide; Hydrocarbon derivative; Aromatic heteropolycyclic compound

2. Physical Properties

SlogP TPSA HBD HBA nHA nRB nAA nAB SMR vdw_vol vdw_area Density
2.4196 86.99 3 5 20 1 12 12 7.08139 334.74 241.156 0.807312

3. Quantum Information

Heat of Formation Dipole Moment Electronegativity Homo Lumo Hardness
-137.90777 2.18 -4.802 -9.06137 -0.54179 4.26

4. Compound Reactivity

DLP nRFG nLMR
0 0 3

5. Topkat Properties

WOE Prediction Ames Prediction DTP Prediction Rat Oral LD50 (g/kg body weight) Rat Inhalational LC50 (mg/m3/h) Chronic LOAEL (g/kg body weight) Skin Irritancy Skin Sensitization Ocular Irritancy Aerobic Biodegradability Prediction Fathead Minnow LC50 (g/l) Daphnia EC50 (mg/l)
Non-Carcinogen Non-Mutagen Toxic 0.748394 2314.49 0.0652765 None Strong Moderate Non-Degradable 0.00490193 4.59146

6. Drug-Likeliness Test

Lipinski's rule of five Jorgensen's rule of three Goshe filter Veber filter PAINS1 PAINS2 PAINS3
Yes Yes Yes Yes Yes Yes Yes

7. Synonyms

Name
apigenin
520-36-5
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Chamomile
Spigenin
Versulin
4',5,7-Trihydroxyflavone
Apigenol
Apigenine
C.I. Natural Yellow 1
5,7,4'-Trihydroxyflavone
Pelargidenon 1449
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
2-(p-Hydroxyphenyl)-5,7-dihydroxychromone
UCCF 031
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
NSC 83244
5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
FLAVONE, 4',5,7-TRIHYDROXY-
CCRIS 3789
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-
CHEBI:18388
CHEMBL28
EINECS 208-292-3
BRN 0262620
4&prime
,5,7-Trihydroxyflavone
KZNIFHPLKGYRTM-UHFFFAOYSA-N
NSC83244
MFCD00006831
NSC-83244
AK-88794
CAS-520-36-5
ST056301
DSSTox_CID_2391
DSSTox_RID_76568
DSSTox_GSID_22391
Q-100586
Q-200822
SMR000326850
UNII-7V515PI7F6
Chamomile Powder
HSDB 7573
4der
4dgm
4hkk
Naringenin, 18
Prestwick_719
Apigenin, 13
PubChem9831
Tocris-1227
3cf9
4',7-Trihydroxyflavone
BiomolKI_000078
Prestwick0_000414
Prestwick1_000414
Prestwick2_000414
Prestwick3_000414
Spectrum2_000428
Spectrum3_001882
Spectrum4_001999
Lopac-A-3145
BiomolKI2_000082
D00RIX
4,5, 7-Trihydroxyflavone
AC1NQX15
Lopac0_000065
Oprea1_622293
SCHEMBL19428
4',5,7-trihydroxy-Flavone
Apigenin, analytical standard
BSPBio_000368
BSPBio_003384
KBioGR_002565
SPECTRUM200846
5-18-04-00574 (Beilstein Handbook Reference)
MLS000697626
MLS000859991
MLS001074874
MLS006011839
BIDD:ER0135
DivK1c_000798
SCHEMBL222227
SPBio_000416
SPBio_002307
ghl.PD_Mitscher_leg0.1194
BDBM7458
BPBio1_000406
GTPL4136
MEGxp0_000176
DTXSID6022391
ACon1_002450
cid_5280443
HMS502H20
KBio1_000798
KBio3_002887
BIK9018
OR7265T
MolPort-001-740-354
NINDS_000798
ZX-AFC000435
7V515PI7F6
BB_NC-1751
Bio1_000376
Bio1_000865
Bio1_001354
HMS1569C10
HMS1922P22
HMS2096C10
HMS2230D17
HMS3260M11
HMS3267D21
HMS3373B18
HMS3561P09
HMS3655D18
Apigenin, >=95.0% (HPLC)
4',5,7-Trihydroxyflavone, 97%
ACN-S003241
HY-N1201
ZINC3871576
ZX-AT019281
Tox21_201542
Tox21_302884
Tox21_500065
BBL010499
BS0030
CCG-40061
GP1532
HSCI1_000221
LMPK12110005
s2262
SBB066087
STK801630
AKOS002140699
AC-8011
AN-8432
CS-5432
DB07352
EBD2138579
LP00065
LS-2209
MCULE-6141069907
ND-9076
SDCCGMLS-0066379.P001
TRA0067512
IDI1_000798
SMP2_000338
Apigenin, >=97% (TLC), from citrus
NCGC00015049-01
NCGC00015049-02
NCGC00015049-03
NCGC00015049-04
NCGC00015049-05
NCGC00015049-06
NCGC00015049-07
NCGC00015049-08
NCGC00015049-09
NCGC00015049-10
NCGC00015049-11
NCGC00015049-12
NCGC00015049-13
NCGC00015049-14
NCGC00015049-15
NCGC00015049-16
NCGC00015049-18
NCGC00025057-01
NCGC00025057-02
NCGC00025057-03
NCGC00025057-04
NCGC00025057-05
NCGC00025057-06
NCGC00025057-07
NCGC00025057-08
NCGC00025057-09
NCGC00169835-01
NCGC00169835-02
NCGC00169835-03
NCGC00256419-01
NCGC00259092-01
NCGC00260750-01
4CN-0925
AJ-46351
CC-24158
CJ-10995
HE004065
HE279357
HE344136
KB-78227
NCI60_041830
SC-05011
SY005957
TS-00897
AB0010536
AB1011450
AX8015784
LY 080400
ST2411642
TC-307820
TR-018510
EU-0100065
FT-0622445
FT-0623582
N1828
20A365
A 3145
C01477
J10341
K00045
M-6923
Apigenin, >=97% (TLC), from parsley, powder
Biochem Biophys Res Comm 212: 767 (1997)
4 inverted exclamation marka,5,7-Trihydroxyflavone
5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one
Apigenin, primary pharmaceutical reference standard
C-16977
4 inverted exclamation mark ,5,7-trihydroxyflavone
I06-0221
BRD-K01493881-001-10-4
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one #
4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-hydroxyphenyl)-
D50A2D8A-6D8B-4708-B21E-2DE9580D033F
Apigenin, United States Pharmacopeia (USP) Reference Standard
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- (9CI)
461015-54-3
4′,5,7-Trihydroxyflavone (apigenin)
SR-01000075663
ACN-034762
BG00617011
BG01563192
SR-01000075663-1
SR-01000075663-3
SR-01000075663-7
SR-01000075663-8

8. Compound in Different Plants

Compound Name Plant Name Compound in Plant Parts Ref
Apigenin
Andrographis paniculata Whole Plant 2 , 29
Anisomeles indica (L.) Kuntze. Whole Plant; Aerial 5 , 4 , 8 , 12
Apium graveolens Seed 10 , 17
Bauhinia variegate 1
Coriandrum sativum Linn. Grass 9
Ichnocarpus frutescens Leaf 8
Ipomoea aquatica Whole Plant 5
Jatropha gossypifolia Leaf 8 , 10 , 18 , 2
Leucas aspera Whole Plant 11
Ludwigia octovalvis 1
Luffa cylindrical (L.) Roem. Leaf 5 , 13
Scoparia dulcia L Aerial; Whole Plant 2 , 16
Sesamum indicum L. Flower 14
Tamarindus indica Pericarp and Seed; Root 6 , 7 , 11

9. Targets

ID Target Name Gene Symbol Organism Protein Crystal Complex Activity Values Reference
Potency (nM) Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) Biological Assay DOI Article PMID PubChem AID
165 15-hydroxyprostaglandin dehydrogenase HPGD Homo sapiens 3.5481 894
165 15-hydroxyprostaglandin dehydrogenase HPGD Homo sapiens 22.3872 894
165 15-hydroxyprostaglandin dehydrogenase HPGD Homo sapiens 28.1838 894
165 15-hydroxyprostaglandin dehydrogenase HPGD Homo sapiens 31.6228 894
217 17-beta-hydroxysteroid dehydrogenase type 3 Homo sapiens 2.13E+4 11496833
217 17-beta-hydroxysteroid dehydrogenase type 3 Homo sapiens 1.64E+4 11496833
834 2,3-bisphosphoglycerate-independent phosphoglycerate mutase PGAM Leishmania major strain Friedlin 19.0115 504548
1 Acetylcholinesterase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 64270
1 Acetylcholinesterase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 121600 10.1016/j.ejmech.2009.09.041 19879672
33 acetylcholinesterase (Cartwright blood group) ACHE Homo sapiens 0.012 1115338
33 acetylcholinesterase (Cartwright blood group) ACHE Homo sapiens 121.6 441660
193 Adenosine receptor Rattus norvegicus 3020 10.1021/jm970446z 9438021
193 Adenosine receptor Rattus norvegicus 3000 10.1021/jm950661k 8576921
313 Adenosine Receptors A2a (A2a) Rattus norvegicus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 7586 10.1021/jm970446z 9438021
313 Adenosine Receptors A2a (A2a) Rattus norvegicus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 7580 10.1021/jm950661k 8576921
69 aldehyde dehydrogenase 1 family member A1 ALDH1A1 Homo sapiens 1.7783 1030
69 aldehyde dehydrogenase 1 family member A1 ALDH1A1 Homo sapiens 6.3096 1030
69 aldehyde dehydrogenase 1 family member A1 ALDH1A1 Homo sapiens 10 1030
69 aldehyde dehydrogenase 1 family member A1 ALDH1A1 Homo sapiens 12.5893 1030
69 aldehyde dehydrogenase 1 family member A1 ALDH1A1 Homo sapiens 25.1189 1030
2 aldo-keto reductase family 1 member B Akr1b1 Rattus norvegicus 6.67 385353
160 Aldose reductase Rattus norvegicus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 6670 10.1021/np070489a 18298080
56 androgen receptor Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 5200 10.1016/j.bmcl.2009.06.073 19592245
56 androgen receptor AR Homo sapiens 1.9331 743042
56 androgen receptor AR Homo sapiens 3.1043 743042
56 androgen receptor AR Homo sapiens 3.3082 743054
56 androgen receptor AR Homo sapiens 4.8972 743035
56 androgen receptor AR Homo sapiens 5.2 429119
56 androgen receptor AR Homo sapiens 6.19396 743054
56 androgen receptor AR Homo sapiens 9.9041 743035
56 androgen receptor AR Homo sapiens 21.6899 1259243
56 androgen receptor AR Homo sapiens 22.3872 588515
56 androgen receptor AR Homo sapiens 22.5385 1259247
56 androgen receptor AR Homo sapiens 25.1189 588515
56 androgen receptor AR Homo sapiens 35.4813 588516
56 androgen receptor AR Homo sapiens 37.4354 743063
56 androgen receptor AR Homo sapiens 39.8107 588516
56 androgen receptor AR Homo sapiens 46.8613 743063
56 androgen receptor AR Homo sapiens 51.1252 1259247
56 androgen receptor AR Homo sapiens 55.2037 1259243
479 angiotensin I converting enzyme ACE Oryctolagus cuniculus 280 612411
479 angiotensin I converting enzyme ACE Oryctolagus cuniculus 280000 464081
429 Angiotensin-converting enzyme Oryctolagus cuniculus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 280000000 10.1016/j.bmcl.2010.01.113 20167484
429 Angiotensin-converting enzyme Oryctolagus cuniculus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 280000 10.1016/j.bmc.2011.06.085 21782455
117 ankyrin-like protein B18R Vaccinia virus 10 720580
117 ankyrin-like protein B18R Vaccinia virus 11.2202 720579
117 ankyrin-like protein B18R Vaccinia virus 11.2202 720580
229 apical membrane antigen 1 AMA1 Plasmodium falciparum 3D7 35.4813 720542
93 arachidonate 15-lipoxygenase ALOX15 Homo sapiens 5.0119 887
194 Aromatase (CYP19) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 10000 10.1016/j.ejmech.2007.11.021 18192087
194 Aromatase (CYP19) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1200 26301554
194 Aromatase (CYP19) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1000 10.1016/j.bmc.2008.08.034 18778944
194 Aromatase (CYP19) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 900 10.1016/j.bmcl.2010.03.113 20413308
24 aryl hydrocarbon receptor AHR Homo sapiens 3.06379 743122
24 aryl hydrocarbon receptor AHR Homo sapiens 6.859 743085
24 aryl hydrocarbon receptor AHR Homo sapiens 21.977 743122
24 aryl hydrocarbon receptor AHR Homo sapiens 24.6586 743085
24 aryl hydrocarbon receptor AHR Homo sapiens 28.1838 651777
24 aryl hydrocarbon receptor AHR Homo sapiens 35.4813 651777
35 arylsulfatase A ARSA Homo sapiens 2.3934 720538
118 ataxin 2 ATXN2 Homo sapiens 3.9811 588378
118 ataxin 2 ATXN2 Homo sapiens 11.2202 651635
234 ATP binding cassette subfamily C member 1 ABCC1 Homo sapiens 4.9 679987
190 ATPase family, AAA domain containing 5 ATAD5 Homo sapiens 2.0588 493107
190 ATPase family, AAA domain containing 5 ATAD5 Homo sapiens 3.2629 493106
190 ATPase family, AAA domain containing 5 ATAD5 Homo sapiens 4.85577 720516
190 ATPase family, AAA domain containing 5 ATAD5 Homo sapiens 4.8558 651632
190 ATPase family, AAA domain containing 5 ATAD5 Homo sapiens 5.5204 651632
190 ATPase family, AAA domain containing 5 ATAD5 Homo sapiens 6.56098 720516
481 ATP-binding cassette sub-family G member 2 Homo sapiens 5900 10.1016/j.bmc.2010.12.043 21354800
481 ATP-binding cassette sub-family G member 2 Homo sapiens 3100 10.1016/j.bmc.2010.12.043 21354800
6 ATP-dependent phosphofructokinase Tb927.3.3270 Trypanosoma brucei brucei TREU927 47.7548 485368
1163 Beta-glucuronidase Rattus norvegicus 2800 10.1016/j.bmcl.2003.11.074 15013012
235 beta-secretase 1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 38500 10.1021/jm201460y 22243648
235 beta-secretase 1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 11310 10.1021/jm201460y 22243648
235 beta-secretase 1 BACE1 Homo sapiens 38.5 656050
235 beta-secretase 1 BACE1 Homo sapiens 38.5 1115336
483 BRCA1, DNA repair associated BRCA1 Homo sapiens 22.3872 624202
36 Butyrylcholine esterase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 37400 10.1016/j.ejmech.2009.09.041 19879672
37 butyrylcholinesterase BCHE Homo sapiens 37.4 441659
7 carbonic anhydrase 1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 4100 10.3109/14756366.2011.643303 22168126
9 carbonic anhydrase 2 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 2700 10.3109/14756366.2011.643303 22168126
484 Carbonic anhydrase 3 (CA III) 11600 10.3109/14756366.2011.643303 22168126
10 carbonic anhydrase 4 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 9100 10.3109/14756366.2011.643303 22168126
959 casein kinase 2 alpha 1 CSNK2A1 Homo sapiens 0.8 352795
959 casein kinase 2 alpha 1 CSNK2A1 Homo sapiens 0.8 1202638
1164 casein kinase 2 alpha 2 CSNK2A2 Homo sapiens 0.8 1202638
1165 casein kinase 2 beta CSNK2B Homo sapiens 0.8 1202638
560 Casein kinase II alpha/beta Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 740 10.1042/BJ20030674 12816539
560 Casein kinase II alpha/beta Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 800 10.1016/j.bmcl.2009.04.076 19414254
238 cationic trypsin LOC780933 Bos taurus 141.5 214874
240 Cell division protein kinase 5 Rattus norvegicus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV >250000 10.1021/np034011s 15043421
52 C-X-C motif chemokine ligand 8 CXCL8 Homo sapiens 66.8242 651758
486 cyclin dependent kinase 6 CDK6 Homo sapiens 1.7 242481
486 cyclin dependent kinase 6 CDK6 Homo sapiens 1.7 1095229
487 Cyclin-Dependent Kinase 1 (CDK1) Marthasterias glacialis 4000 10.1021/jm049353p 15689157
241 cyclin-dependent kinase 5 Cdk5 Rattus norvegicus 250 400266
489 Cyclin-Dependent Kinase 5 (CDK5) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1600 10.1021/jm049353p 15689157
490 Cyclin-Dependent Kinase 6 (CDK6) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1700 10.1021/jm049353p 15689157
112 Cyclooxygenase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 8000 10.1021/np049655u 16038536
491 cystic fibrosis transmembrane conductance regulator Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 81 10.1016/j.ejmech.2014.07.013 25019478
491 cystic fibrosis transmembrane conductance regulator Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 9 10.1016/j.ejmech.2014.07.013 25019478
491 cystic fibrosis transmembrane conductance regulator CFTR Homo sapiens 9 1183557
491 cystic fibrosis transmembrane conductance regulator CFTR Homo sapiens 81 1183558
242 Cytochrome P450 1A1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 427 10.1016/j.bmc.2010.07.020 20696580
242 Cytochrome P450 1A1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 390 10.1016/j.bmc.2011.03.042 21482471
107 Cytochrome P450 1A2 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 795 10.1016/j.bmc.2010.07.020 20696580
243 Cytochrome P450 1B1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 25 10.1016/j.bmc.2010.07.020 20696580
243 Cytochrome P450 1B1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 64 10.1016/j.bmc.2011.03.042 21482471
492 cytochrome P450 family 1 subfamily A member 1 CYP1A1 Homo sapiens 0.427 502474
108 cytochrome P450 family 1 subfamily A member 2 CYP1A2 Homo sapiens 0.795 502473
493 cytochrome P450 family 1 subfamily B member 1 CYP1B1 Homo sapiens 0.025 502475
79 cytochrome P450 family 19 subfamily A member 1 CYP19A1 Homo sapiens 0.9 479369
79 cytochrome P450 family 19 subfamily A member 1 CYP19A1 Homo sapiens 1.2 1250230
79 cytochrome P450 family 19 subfamily A member 1 CYP19A1 Homo sapiens 1.2197 743083
79 cytochrome P450 family 19 subfamily A member 1 CYP19A1 Homo sapiens 3.1043 743083
79 cytochrome P450 family 19 subfamily A member 1 CYP19A1 Homo sapiens 10 364069
244 cytochrome P450 family 2 subfamily C member 19 CYP2C19 Homo sapiens 7.9433 899
244 cytochrome P450 family 2 subfamily C member 19 CYP2C19 Homo sapiens 19.9526 899
245 cytochrome P450 family 2 subfamily C member 9 CYP2C9 Homo sapiens 5.0119 883
245 cytochrome P450 family 2 subfamily C member 9 CYP2C9 Homo sapiens 31.6228 883
158 cytochrome P450 family 2 subfamily D member 6 CYP2D6 Homo sapiens 12.5893 891
158 cytochrome P450 family 2 subfamily D member 6 CYP2D6 Homo sapiens 39.8107 891
114 cytochrome P450 family 3 subfamily A member 4 CYP3A4 Homo sapiens 1.2589 884
114 cytochrome P450 family 3 subfamily A member 4 CYP3A4 Homo sapiens 1.2589 885
114 cytochrome P450 family 3 subfamily A member 4 CYP3A4 Homo sapiens 3.1623 884
114 cytochrome P450 family 3 subfamily A member 4 CYP3A4 Homo sapiens 3.1623 885
114 cytochrome P450 family 3 subfamily A member 4 CYP3A4 Homo sapiens 7.9433 884
114 cytochrome P450 family 3 subfamily A member 4 CYP3A4 Homo sapiens 7.9433 885
246 death associated protein kinase 1 DAPK1 Homo sapiens 31 1247840
247 Death-associated protein kinase 1 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 31000 26322379
495 Dipeptidyl peptidase III Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 5.40E+4 27754592
249 DNA polymerase eta POLH Homo sapiens 31.6228 588591
65 DNA polymerase iota POLI Homo sapiens 12.5893 588590
197 DNA polymerase kappa POLK Homo sapiens 19.9526 588579
253 Enoyl-acyl-carrier protein reductase Plasmodium falciparum 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 50000 10.1021/jm0600545 16722653
585 Epidermal growth factor receptor Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 3 10.1021/np50089a001
1028 Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 710 10.1021/jm800054h 18533708
587 Estradiol 17-beta-dehydrogenase 2 Homo sapiens >20000 10.1021/jm800054h 18533708
1166 Estrogen receptor Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 130 12824043
1166 Estrogen receptor Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1253 12824043
57 estrogen receptor 1 ESR1 Ovis aries 0.66 69702
57 estrogen receptor 1 ESR1 Homo sapiens 3.9811 588514
57 estrogen receptor 1 ESR1 Homo sapiens 7.8671 743075
57 estrogen receptor 1 ESR1 Homo sapiens 9.6885 1259383
57 estrogen receptor 1 ESR1 Homo sapiens 9.7712 743075
57 estrogen receptor 1 ESR1 Homo sapiens 10.2915 743077
57 estrogen receptor 1 ESR1 Homo sapiens 10.9635 743069
57 estrogen receptor 1 ESR1 Homo sapiens 10.9649 743077
57 estrogen receptor 1 ESR1 Homo sapiens 19.587 1259248
57 estrogen receptor 1 ESR1 Homo sapiens 21.977 1259383
57 estrogen receptor 1 ESR1 Homo sapiens 22.1725 743069
57 estrogen receptor 1 ESR1 Homo sapiens 25.1189 588513
57 estrogen receptor 1 ESR1 Homo sapiens 27.6674 1259244
57 estrogen receptor 1 ESR1 Homo sapiens 28.1838 588514
57 estrogen receptor 1 ESR1 Homo sapiens 30.6379 743080
57 estrogen receptor 1 ESR1 Homo sapiens 30.6379 743091
57 estrogen receptor 1 ESR1 Homo sapiens 30.6379 1259244
57 estrogen receptor 1 ESR1 Homo sapiens 31.3194 743078
57 estrogen receptor 1 ESR1 Homo sapiens 33.082 1259248
57 estrogen receptor 1 ESR1 Homo sapiens 39.8107 588513
57 estrogen receptor 1 ESR1 Homo sapiens 41.205 743078
57 estrogen receptor 1 ESR1 Homo sapiens 43.8499 743091
57 estrogen receptor 1 ESR1 Homo sapiens 49.2004 743080
57 estrogen receptor 1 ESR1 Homo sapiens 54.4827 743079
57 estrogen receptor 1 ESR1 Homo sapiens 61.9396 743079
49 estrogen receptor 2 ESR2 Ovis aries 0.66 69702
49 estrogen receptor 2 ESR2 Homo sapiens 5.4483 1259377
49 estrogen receptor 2 ESR2 Homo sapiens 6.47528 1259394
49 estrogen receptor 2 ESR2 Homo sapiens 8.7492 1259394
49 estrogen receptor 2 ESR2 Homo sapiens 24.3365 1259378
49 estrogen receptor 2 ESR2 Homo sapiens 24.6586 1259377
49 estrogen receptor 2 ESR2 Homo sapiens 27.6674 1259378
25 estrogen related receptor alpha ESRRA Homo sapiens 2.1132 1224823
25 estrogen related receptor alpha ESRRA Homo sapiens 2.6603 1224819
25 estrogen related receptor alpha ESRRA Homo sapiens 2.6603 1224821
25 estrogen related receptor alpha ESRRA Homo sapiens 2.83743 1259401
25 estrogen related receptor alpha ESRRA Homo sapiens 3.3491 1224820
25 estrogen related receptor alpha ESRRA Homo sapiens 3.8571 1224841
25 estrogen related receptor alpha ESRRA Homo sapiens 3.8571 1224842
25 estrogen related receptor alpha ESRRA Homo sapiens 4.8558 1224848
25 estrogen related receptor alpha ESRRA Homo sapiens 4.8558 1224849
25 estrogen related receptor alpha ESRRA Homo sapiens 5.5204 1224848
25 estrogen related receptor alpha ESRRA Homo sapiens 5.66142 1259403
25 estrogen related receptor alpha ESRRA Homo sapiens 6.194 1224842
25 estrogen related receptor alpha ESRRA Homo sapiens 6.194 1224849
25 estrogen related receptor alpha ESRRA Homo sapiens 6.68809 1259403
25 estrogen related receptor alpha ESRRA Homo sapiens 6.68809 1259401
25 estrogen related receptor alpha ESRRA Homo sapiens 7.7977 1224841
256 flap structure-specific endonuclease 1 FEN1 Homo sapiens 10.6213 588795
13 fms related tyrosine kinase 3 FLT3 Homo sapiens 1.45 730328
257 G protein subunit alpha i1 GNAI1 Homo sapiens 25.1189 879
84 geminin, DNA replication inhibitor GMNN Homo sapiens 12.5893 463097
26 GLI family zinc finger 3 GLI3 Homo sapiens 30.6379 1259369
26 GLI family zinc finger 3 GLI3 Homo sapiens 76.9588 1259368
26 GLI family zinc finger 3 GLI3 Homo sapiens 31.0433 1259392
26 GLI family zinc finger 3 GLI3 Homo sapiens 38.5708 1259392
73 glucosylceramidase beta GBA Homo sapiens 7.0795 2101
73 glucosylceramidase beta GBA Homo sapiens 8.9125 2101
73 glucosylceramidase beta GBA Homo sapiens 11.2202 2101
73 glucosylceramidase beta GBA Homo sapiens 12.5893 2101
73 glucosylceramidase beta GBA Homo sapiens 19.9526 2101
43 glutaminase GLS Homo sapiens 35.4813 624170
15 glycogen synthase kinase 3 beta GSK3B Homo sapiens 1.9 1115335
15 glycogen synthase kinase 3 beta GSK3B Homo sapiens 49.49 434954
128 Glycogen Synthase Kinase-3, beta Rattus norvegicus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1400 10.1021/jm049353p 15689157
128 Glycogen Synthase Kinase-3, beta Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 49490 434954
58 heat shock protein family B (small) member 1 HSPB1 Homo sapiens 13.8022 743210
984 hemoglobin subunit beta HBB Homo sapiens 31.6228 930
27 histone deacetylase 9 HDAC9 Homo sapiens 8.7492 1259364
27 histone deacetylase 9 HDAC9 Homo sapiens 17.2289 1259364
27 histone deacetylase 9 HDAC9 Homo sapiens 8.7492 1259388
27 histone deacetylase 9 HDAC9 Homo sapiens 12.6743 1259388
92 histone H2AX LOC100757539 Cricetulus griseus 44.9878 1224896
92 histone H2AX LOC100757539 Cricetulus griseus 48.3223 1224896
92 histone H2AX LOC100757539 Cricetulus griseus 50.4772 1224845
92 histone H2AX LOC100757539 Cricetulus griseus 91.0222 1224845
501 Human diphtheria toxin-like ADP-ribosyltransferase (ARTD5 or PARP5a) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 3100 10.1021/jm3018783 23574272
502 Human diphtheria toxin-like ADP-ribosyltransferase (ARTD6 or PARP5b) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 2900 10.1021/jm3018783 23574272
265 Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 1500 10.1016/j.bmc.2014.04.016 24794743
265 Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H >20000 10.1016/j.bmc.2014.04.016 24794743
1031 hydroxysteroid 17-beta dehydrogenase 1 HSD17B1 Homo sapiens 0.71 406995
603 hydroxysteroid 17-beta dehydrogenase 2 HSD17B2 Homo sapiens 20 406997
82 hypoxia inducible factor 1 subunit alpha HIF1A Homo sapiens 1.9953 914
82 hypoxia inducible factor 1 subunit alpha HIF1A Homo sapiens 1.9953 915
82 hypoxia inducible factor 1 subunit alpha HIF1A Homo sapiens 12.5893 914
82 hypoxia inducible factor 1 subunit alpha HIF1A Homo sapiens 12.5893 915
82 hypoxia inducible factor 1 subunit alpha HIF1A Homo sapiens 54.9477 1224846
82 hypoxia inducible factor 1 subunit alpha HIF1A Homo sapiens 62.4905 1224846
44 inositol monophosphatase 1 Impa1 Rattus norvegicus 3.9811 901
303 isocitrate dehydrogenase (NADP(+)) 1, cytosolic IDH1 Homo sapiens 18.3564 686970
85 Jun proto-oncogene, AP-1 transcription factor subunit JUN Homo sapiens 19.7612 1159526
28 lamin A/C LMNA Homo sapiens 11.2202 1487
28 lamin A/C LMNA Homo sapiens 12.5893 1459
28 lamin A/C LMNA Homo sapiens 12.5893 1487
504 Lck Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 4 10.1021/np50089a001
204 lipoxygenase LOX1.1 Glycine max 178.3 1063895
204 lipoxygenase LOX1.1 Glycine max 191 1063897
204 lipoxygenase LOX1.1 Glycine max 191.4 1063899
205 Lipoxygenase-1 Glycine max 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 178300 10.1016/j.ejmech.2013.11.030 24368208
115 lysine methyltransferase 2A KMT2A Homo sapiens 8.9125 1768
115 lysine methyltransferase 2A KMT2A Homo sapiens 10 1768
115 lysine methyltransferase 2A KMT2A Homo sapiens 22.3872 1768
115 lysine methyltransferase 2A KMT2A Homo sapiens 39.8107 1766
115 lysine methyltransferase 2A KMT2A Homo sapiens 39.8107 1768
115 lysine methyltransferase 2A KMT2A Homo sapiens 15.8489 1766
1167 Lysozyme C Rattus norvegicus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 17700 10.1016/j.bmcl.2003.11.074 15013012
271 Lysyl-tRNA synthetase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 3000 10.1021/jm201271b 22257213
271 Lysyl-tRNA synthetase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 4200 10.1021/jm201271b 22257213
116 menin 1 MEN1 Homo sapiens 8.9125 1768
116 menin 1 MEN1 Homo sapiens 10 1768
116 menin 1 MEN1 Homo sapiens 15.8489 1766
116 menin 1 MEN1 Homo sapiens 22.3872 1768
116 menin 1 MEN1 Homo sapiens 39.8107 1766
116 menin 1 MEN1 Homo sapiens 39.8107 1768
16 microtubule associated protein tau MAPT Homo sapiens 3.1623 1460
16 microtubule associated protein tau MAPT Homo sapiens 8.9125 1460
16 microtubule associated protein tau MAPT Homo sapiens 10 1460
16 microtubule associated protein tau MAPT Homo sapiens 15.8489 1460
16 microtubule associated protein tau MAPT Homo sapiens 35.4813 1468
86 mitogen-activated protein kinase 1 MAPK1 Homo sapiens 19.9526 995
274 Mitogen-activated protein kinase 10 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 2.20E+3 10.1002/cbic.201000487 21108268
275 Mitogen-activated protein kinase 14 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1.43E+4 10.1002/cbic.201000487 21108268
211 Monoamine oxidase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1700 10.1016/j.bmc.2009.12.029 20045650
211 Monoamine oxidase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 12800 10.1016/j.bmc.2009.12.029 20045650
276 M-phase phosphoprotein 8 MPHOSPH8 Homo sapiens 0.7943 488949
277 Multidrug resistance protein 1 (MRP1) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 2400 10.1021/jm900194w 19725578
277 Multidrug resistance protein 1 (MRP1) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 4900 11306701
513 NADPH oxidase 4 Homo sapiens 1130 10.1021/jm1004368 20731357
279 neuraminidase 2 NEU2 Homo sapiens 570 466938
621 neuropeptide S receptor 1 NPSR1 Homo sapiens 25.1189 1461
369 NPC intracellular cholesterol transporter 1 NPC1 Homo sapiens 5.8048 485313
29 nuclear factor kappa B subunit 1 NFKB1 Homo sapiens 19.9526 895
29 nuclear factor kappa B subunit 1 NFKB1 Homo sapiens 19.9526 928
29 nuclear factor kappa B subunit 1 NFKB1 Homo sapiens 48.9722 1159509
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 0.4611 504444
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 8.6349 720636
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 10.5909 720636
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 10.8707 743219
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 22.8368 743219
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 24.3365 651741
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 27.6674 743202
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 33.4915 651741
30 nuclear factor, erythroid 2 like 2 NFE2L2 Homo sapiens 76.9588 743202
89 nuclear receptor subfamily 1 group H member 4 NR1H4 Homo sapiens 15.6969 743217
89 nuclear receptor subfamily 1 group H member 4 NR1H4 Homo sapiens 38.9 743217
89 nuclear receptor subfamily 1 group H member 4 NR1H4 Homo sapiens 44.6684 588526
89 nuclear receptor subfamily 1 group H member 4 NR1H4 Homo sapiens 50.1187 588526
83 nuclear receptor subfamily 1 group I member 2 NR1I2 Homo sapiens 31.6228 720659
83 nuclear receptor subfamily 1 group I member 2 NR1I2 Homo sapiens 44.6684 720659
80 nuclear receptor subfamily 1 group I member 3 NR1I3 Homo sapiens 24.6586 1224839
80 nuclear receptor subfamily 1 group I member 3 NR1I3 Homo sapiens 27.6674 1224838
80 nuclear receptor subfamily 1 group I member 3 NR1I3 Homo sapiens 27.6674 1224893
80 nuclear receptor subfamily 1 group I member 3 NR1I3 Homo sapiens 54.4827 1224838
80 nuclear receptor subfamily 1 group I member 3 NR1I3 Homo sapiens 54.4827 1224893
80 nuclear receptor subfamily 1 group I member 3 NR1I3 Homo sapiens 61.1306 1224839
55 nuclear receptor subfamily 3 group C member 1 NR3C1 Homo sapiens 0.0071 588532
55 nuclear receptor subfamily 3 group C member 1 NR3C1 Homo sapiens 27.5391 720692
55 nuclear receptor subfamily 3 group C member 1 NR3C1 Homo sapiens 27.9135 720692
55 nuclear receptor subfamily 3 group C member 1 NR3C1 Homo sapiens 31.6228 588533
55 nuclear receptor subfamily 3 group C member 1 NR3C1 Homo sapiens 39.8107 588533
55 nuclear receptor subfamily 3 group C member 1 NR3C1 Homo sapiens 44.6684 588532
55 nuclear receptor subfamily 3 group C member 1 NR3C1 Homo sapiens 62.4905 720691
361 parathyroid hormone 1 receptor PTH1R Homo sapiens 50.1187 743266
632 parkin RBR E3 ubiquitin protein ligase PRKN Homo sapiens 3.2643 720573
632 parkin RBR E3 ubiquitin protein ligase PRKN Homo sapiens 16.3601 720572
180 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 PIN1 Homo sapiens 37.933 504536
180 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 PIN1 Homo sapiens 79.4328 504891
31 peripheral myelin protein 22 PMP22 Homo sapiens 60.1198 1967
53 peroxisome proliferator activated receptor delta PPARD Homo sapiens 17.376 743215
53 peroxisome proliferator activated receptor delta PPARD Homo sapiens 17.7828 588534
53 peroxisome proliferator activated receptor delta PPARD Homo sapiens 39.8107 588535
72 peroxisome proliferator activated receptor gamma Pparg Mus musculus 24.9 1180479
72 peroxisome proliferator activated receptor gamma PPARG Homo sapiens 4.36465 743140
72 peroxisome proliferator activated receptor gamma PPARG Homo sapiens 6.1652 743094
72 peroxisome proliferator activated receptor gamma PPARG Homo sapiens 8.9125 588536
72 peroxisome proliferator activated receptor gamma PPARG Homo sapiens 13.9899 743094
72 peroxisome proliferator activated receptor gamma PPARG Homo sapiens 21.8751 743191
72 peroxisome proliferator activated receptor gamma PPARG Homo sapiens 44.6684 588537
372 Peroxisome proliferator-activated receptor gamma Mus musculus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 24900 10.1021/np500150f 24955889
514 P-glycoprotein 1 (Pgp/MDR1) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 10000 10.1016/j.ejmech.2011.06.008 21723648
284 PIM-1 Kinase (PIM1) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 940 10.1158/1535-7163.MCT-06-0397 17218638
515 poly(ADP-ribose) polymerase 1 PARP1 Homo sapiens 100 735783
516 poly-ADP-ribose polymerase 1 (PARP1) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 100000 10.1021/jm3018783 23574272
288 Protein kinase Pfmrk Plasmodium falciparum 7000 10.1021/jm040108f 15481979
19 Protein-tyrosine phosphatase 1B (PTP1B) Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 100000
945 pyruvate kinase M1/2 PKM Homo sapiens 3.1623 954
945 pyruvate kinase M1/2 PKM Homo sapiens 3.1623 958
71 RAR related orphan receptor C RORC Homo sapiens 4.2163 651802
50 RAR-related orphan receptor gamma Rorc Mus musculus 0.5623 2546
50 RAR-related orphan receptor gamma Rorc Mus musculus 4.2199 1159523
50 RAR-related orphan receptor gamma Rorc Mus musculus 4.32771 1159523
50 RAR-related orphan receptor gamma Rorc Mus musculus 5.5204 1159521
50 RAR-related orphan receptor gamma Rorc Mus musculus 14.1254 2551
50 RAR-related orphan receptor gamma Rorc Mus musculus 35.4813 2551
50 RAR-related orphan receptor gamma Rorc Mus musculus 4.8558 1159521
289 Receptor-type tyrosine-protein kinase FLT3 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 1450 10.1016/j.bmcl.2013.01.049 23411073
290 regulator of G protein signaling 12 RGS12 Homo sapiens 25.1189 879
291 regulator of G protein signaling 4 RGS4 Homo sapiens 16.8336 504845
51 retinoic acid receptor alpha RARA Homo sapiens 1.0871 1159553
51 retinoic acid receptor alpha RARA Homo sapiens 1.42208 1159555
51 retinoic acid receptor alpha RARA Homo sapiens 1.5559 1159553
51 retinoic acid receptor alpha RARA Homo sapiens 1.7229 1159552
51 retinoic acid receptor alpha RARA Homo sapiens 2.1977 1159552
51 retinoic acid receptor alpha RARA Homo sapiens 2.87498 1159555
54 retinoid X receptor alpha RXRA Homo sapiens 12.3013 1159527
54 retinoid X receptor alpha RXRA Homo sapiens 12.5893 588544
54 retinoid X receptor alpha RXRA Homo sapiens 15.8489 588546
54 retinoid X receptor alpha RXRA Homo sapiens 16.7218 1159531
54 retinoid X receptor alpha RXRA Homo sapiens 19.7612 1159527
54 retinoid X receptor alpha RXRA Homo sapiens 20.5343 1159531
54 retinoid X receptor alpha RXRA Homo sapiens 28.1838 588544
54 retinoid X receptor alpha RXRA Homo sapiens 28.1838 588546
20 Serine/threonine-protein kinase Aurora-B Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 3.96E+3 10.1111/cbdd.12445 25298094
294 Serine/threonine-protein kinase PIM 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 933 10.1016/j.bmc.2007.06.025 17637507
520 Sialidase Clostridium perfringens 17400 10.1016/j.bmc.2009.02.042 19285413
520 Sialidase Clostridium perfringens 17400 10.1016/j.bmc.2009.08.036 19729316
295 Sialidase 2 Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 570000 10.1016/j.bmc.2009.12.062 20097567
66 SMAD family member 3 SMAD3 Homo sapiens 35.4813 588855
297 spleen associated tyrosine kinase SYK Homo sapiens 3 701064
297 spleen associated tyrosine kinase SYK Homo sapiens 4.2 701071
453 survival of motor neuron 2, centromeric SMN2 Homo sapiens 14.1254 1458
453 survival of motor neuron 2, centromeric SMN2 Homo sapiens 22.3872 1458
453 survival of motor neuron 2, centromeric SMN2 Homo sapiens 25.1189 1458
453 survival of motor neuron 2, centromeric SMN2 Homo sapiens 35.4813 1458
522 tankyrase TNKS Homo sapiens 3.16228 735786
523 tankyrase 2 TNKS2 Homo sapiens 2.95121 735784
46 thrombopoietin THPO Homo sapiens 0.5012 917
46 thrombopoietin THPO Homo sapiens 0.5012 918
47 thyroid hormone receptor beta Thrb Rattus norvegicus 28.3743 743067
47 thyroid hormone receptor beta Thrb Rattus norvegicus 30.6379 743065
47 thyroid hormone receptor beta Thrb Rattus norvegicus 61.9396 743065
47 thyroid hormone receptor beta Thrb Rattus norvegicus 61.9396 743067
47 thyroid hormone receptor beta THRB Homo sapiens 39.8107 1479
47 thyroid hormone receptor beta THRB Homo sapiens 50.1187 1469
32 thyroid stimulating hormone receptor TSHR Homo sapiens 3.9811 926
524 transthyretin TTR Homo sapiens 0.25 1239060
524 transthyretin TTR Homo sapiens 18 1239061
525 Transthyretin (TTR) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 653
525 Transthyretin (TTR) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 18000 26214366
525 Transthyretin (TTR) 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 250 26214366
209 Trypsin Bos taurus 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV,5I2H 141500 10.1021/jm970245v 9406602
81 tumor protein p53 TP53 Homo sapiens 3.9811 902
81 tumor protein p53 TP53 Homo sapiens 5.0119 924
81 tumor protein p53 TP53 Homo sapiens 15.5585 651631
81 tumor protein p53 TP53 Homo sapiens 15.8489 902
81 tumor protein p53 TP53 Homo sapiens 18.8496 720552
81 tumor protein p53 TP53 Homo sapiens 31.6228 651743
81 tumor protein p53 TP53 Homo sapiens 35.4813 651743
81 tumor protein p53 TP53 Homo sapiens 43.2771 651631
81 tumor protein p53 TP53 Homo sapiens 52.4314 720552
78 Tyrosinase Agaricus bisporus 305000 10.1021/np800564z 18986201
67 tyrosyl-DNA phosphodiesterase 1 TDP1 Homo sapiens 5.1735 686978
67 tyrosyl-DNA phosphodiesterase 1 TDP1 Homo sapiens 12.9953 686978
67 tyrosyl-DNA phosphodiesterase 1 TDP1 Homo sapiens 18.3564 686979
67 tyrosyl-DNA phosphodiesterase 1 TDP1 Homo sapiens 23.715 686979
67 tyrosyl-DNA phosphodiesterase 1 TDP1 Homo sapiens 29.8554 686978
67 tyrosyl-DNA phosphodiesterase 1 TDP1 Homo sapiens 33.4983 686978
67 tyrosyl-DNA phosphodiesterase 1 TDP1 Homo sapiens 53.0912 686979
126 ubiquitin specific peptidase 1 USP1 Homo sapiens 4.4668 504865
300 ubiquitin specific peptidase 2 USP2 Homo sapiens 10 927
64 vitamin D receptor VDR Homo sapiens 39.8107 588541
64 vitamin D receptor VDR Homo sapiens 48.9722 743223
526 xanthine dehydrogenase XDH Homo sapiens 0.52 1183551
526 xanthine dehydrogenase XDH Homo sapiens 3.2 1234421
302 Xanthine oxidase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 520 10.1016/j.ejmech.2014.07.013 25019478
302 Xanthine oxidase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 3200 10.1016/j.bmcl.2015.05.016 26022844
302 Xanthine oxidase Homo sapiens 3AMY,3CF9,4DER,4DGM,4HKK,4WO0,5AUV 700 10.1021/np970237h 9461655

10. Chemical Vendors

SID Source Name Source URL Source Detail Registry ID Source Record URL
162172991AK Scientific, Inc. (AKSCI)Source URLSource Detail67556Source Record URL
277309380AK Scientific, Inc. (AKSCI)Source URLSource DetailJ10341Source Record URL
143438565TimTecSource URLSource DetailSBB066087Source Record URL
124557885TimTecSource URLSource DetailST056301Source Record URL
3562824611717 CheMall CorporationSource URLSource DetailBG00617011Source Record URL
3569124611717 CheMall CorporationSource URLSource DetailBG01563192Source Record URL
3629251241717 CheMall CorporationSource URLSource DetailBG04608953Source Record URL
3597290151717 CheMall CorporationSource URLSource DetailBG06573194Source Record URL
3608438401717 CheMall CorporationSource URLSource DetailBG07656507Source Record URL
251911842AvaChem ScientificSource URLSource Detail1210Source Record URL
329747355Sigma-AldrichSource URLSource Detail01760595_SIALSource Record URL
329749048Sigma-AldrichSource URLSource Detail1040683_USPSource Record URL
57646817Sigma-AldrichSource URLSource Detail10798_SIGMASource Record URL
329756029Sigma-AldrichSource URLSource Detail42251_SIALSource Record URL
24278212Sigma-AldrichSource URLSource DetailA3145_SIGMASource Record URL
348356945Sigma-AldrichSource URLSource DetailSMB00702_SIGMASource Record URL
126631296ChemMolSource URLSource Detail30101532Source Record URL
126664260ChemMolSource URLSource Detail49402836Source Record URL
135716221ChemMolSource URLSource Detail97800292Source Record URL
135697787ChemMolSource URLSource Detail97900274Source Record URL
241090044ChemMolSource URLSource Detail99099148Source Record URL
163688593EMD MilliporeSource URLSource Detail178278Source Record URL
316435082abcr GmbHSource URLSource DetailAB179962Source Record URL
316580747abcr GmbHSource URLSource DetailAB402813Source Record URL
312808031Achemo Scientific LimitedSource URLSource DetailAC-15803Source Record URL
136023253ABBLIS ChemicalsSource URLSource DetailAB1011450Source Record URL
318367904CambridgeChemSource URLSource DetailB15784Source Record URL
329970652CambridgeChemSource URLSource DetailP0318Source Record URL
329972033CambridgeChemSource URLSource Detailwkq-00433Source Record URL
252159233Acorn PharmaTech Product ListSource URLSource DetailACN-034762Source Record URL
137292765Acorn PharmaTech Product ListSource URLSource DetailACN-S003241Source Record URL
81041032ISpharmSource URLSource DetailI06-0221Source Record URL
341831016OChemSource URLSource Detail842Source Record URL
347913055SelleckchemSource URLSource DetailS2262Source Record URL
87562965TCI (Tokyo Chemical Industry)Source URLSource DetailA1514Source Record URL
254761156Boc SciencesSource URLSource Detail520-36-5Source Record URL
223555522A&J Pharmtech CO., LTD.Source URLSource DetailAJ-46351Source Record URL
223496349A&J Pharmtech CO., LTD.Source URLSource DetailCJ-10995Source Record URL
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